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Published studies have investigated retatrutide as a ligand with activity reported across GLP 1, GIP, and glucagon receptors, with research interest spanning energy balance and glucose regulation pathways

Evidence and Research Comparison# Mazdutide Research# Mazdutide was approved in China in June 2025 for weight management, making it the first GLP-1/glucagon dual agonist to receive regulatory approval anywhere: Phase 3 obesity (China) : Up to 20.1% body weight reduction at the 9 mg dose over 60 weeks