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OH acquires hydrogen atoms to form lipid radicals (L), also known as pentadienyl radicals), which then react with oxygen molecules to create lipid peroxyl radicals (LOO) (Ayala et al., 2014)
To further confirm the involvement of Nrf2, Nrf2 expression was down-regulated by Nrf2 siRNA transfection, which significantly increased the expression of inflammatory factors including IL-6, iNOS, as well as the cartilage matrix degradation factor, MMP13, in chondrocytes treated with metformin
Aim to build up gradually and find activities you enjoy, as this helps make exercise a sustainable habit
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