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In a small open-label trial of exenatide in people with clozapine-associated obesity (BMI 3045 kg/m 2 ), those on exenatide had about 10 pounds more weight loss than placebo at 24 weeks (Siskind D et al, J Psychiatr Res 2020;124:912)
Occasional ibuprofen use is often acceptable, but regular NSAID use alongside semaglutide increases gastrointestinal irritation and ulcer risk because both affect the stomach lining
The app helps keep slower stretches readable enough that they do not erase momentum
For individuals actively trying to conceive, discontinuation with appropriate washout periods is essential
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