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What is worth to summarize here is the fact that several pro-apoptotic stimuli induce an early extrusion of GSH from cells leading to a widespread mitochondrial damage and to cytochrome c release into the cytosol, the starting condition for apoptotic intrinsic pathway commitment
Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands
Moreover, ferroptosis contributes to fibrosis in multiple organs, such as the lungs, heart, and liver [18,19,20]