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Serious adverse reactions can include: Signs of an allergic reaction such as hives, difficulty breathing, or swelling in your face or throat Alterations in mood and behavior including increased risk of suicidal thoughts especially among teenagers Sudden changes in vision like blurred sight or eye pain Unusual bleeding or bruising Liver problems which might manifest as right-sided abdominal pain, vomiting, loss of appetite, dark urine coloration Skin reactions including severe rash and blisters that may lead to peeling Problems with urination - either too much or too little

The good news is that there is no official contraindication to taking these medications together, and no direct pharmacological interaction has been established between semaglutide and bupropion

Cell 183 , 636649.e18 (2020)