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The usual clinical aspect is a grey, bluish-grey or black macular stain, which is usually seen on the gingival or alveolar mucosa
The most commonly reported include: Nausea Constipation or diarrhoea Heartburn or reflux Feeling overly full Reduced appetite that can lead to under-eating Practical pharmacist guidance that helps: Smaller meals, slower eating, prioritise protein and fibre Hydration targets and electrolytes when needed Dose timing strategies and symptom tracking Reviewing other medicines (some can worsen nausea or constipation) Seek urgent medical advice for severe or persistent symptoms, especially severe abdominal pain, vomiting that does not settle, or signs of dehydration
demonstrated that the timing of Ex-4 administration critically influences osteogenic differentiation of hMSC
That is why supervised administration and regular follow-up are non-negotiable at our clinic
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