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The nAChRs can respond to a relatively low concentration that can be safely attained in the extra-synaptic region, which lends support to the concept of a comparable paracrine wide distance range known as volume transmission [16]
Indeed, mass spectrometry revealed that cleavage by X(PC) occurred between Glu 314 and Asp 315 rather than the predicted site between Asp 316 and Ala 317 inferred from its alignment with VAMP1 (Fig
One significant gap involves the insufficient comprehension of how genetic evolution and epigenetic plasticity interact over time under therapy-induced selection pressure
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