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GLP-1 receptor agonists, including semaglutide and liraglutide, are FDA-approved medications for type 2 diabetes and obesity management
They blunt activation of nuclear factor kappa B (NFB), reducing transcription of inflammatory mediators, and promote anti-inflammatory signaling and metabolic equilibrium via AMP-activated kinase (AMPK) activation
Thus, while each platform has demonstrated proof-of-concept efficacy, the choice of design must balance responsiveness, stability, and biosafety to ensure clinical applicability
at the end of the treatment, a 2.3 point improvement was noted in the exenatide group compared with a 1.7 point deterioration in the placebo group
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