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Triple Agonist A medication targeting three different receptors simultaneously

LCA (and its high affinity conjugate TLCA) as a strong TGR5 agonist activates cAMP STAT3/STAT6 and the inflammatory immunosuppressive pathway in the liver that bias macrophages toward immunosuppressive states, which establishes a pro-tumor microenvironment conducive to HCC progression [48, 191]

however, injections may cause side effects

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