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Losing muscle: Reduces metabolic rate , making it harder to maintain weight loss Increases frailty , especially in older adults Raises the risk of chronic conditions like diabetes, heart disease, and osteoporosis The rise of GLP-1 receptor agonists (e.g., semaglutide and tirzepatide) has amplified this concern

CJC-1295 and Ipamorelin offer smoother and more efficient growth hormone delivery

Optimising thyroid replacement and evidence-based lifestyle interventions should be explored as first-line approaches before considering GLP-1 medications

The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice