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A Y1R germline deletion results in elevated osteoblast activity and mineral apposition rate, together with increased formation of highly multinucleated osteoclasts and enhanced surface area, demonstrating a negative role of Y1R on bone mass maintenance [76]
This makes it an effective option for those seeking to maintain overall wellness
For pure weight loss, tirzepatide produces roughly a third more loss on average and has a slightly cleaner GI discontinuation profile in the only head-to-head trial that exists
2020 Mar;212(4):175-183
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