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Based on the 2026 Clinical Obesity review of 480,825 adults, the most commonly deficient nutrients in GLP-1 users are vitamin D (13.6% deficient by 12 months), iron (2630% lower ferritin than comparators), calcium, and B12

Severe deficiency causes irreversible neurological damage and subacute combined degeneration of the spinal cord, a condition that does not fully reverse even with aggressive B12 repletion

When paired with a balanced diet and regular exercise, they amplify weight loss results, helping you achieve and sustain your goals

These conditions and causes include emphysema, asthma, allergic disorders, drug toxicity, metabolic disorders, cancer, chemotherapy and human immunodeficiency virus-acquired immune deficiency syndrome, among others