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Do KQ, Bovet P, Cabungcal JH, Conus P, Gysin R, Lavoie S et al Redox dysregulation in schizophrenia: genetic susceptibility and pathophysiological mechanisms
Mechanistically it adds steric and electrostatic bulk at the same end of the molecule the binding proteins engage, deepening the reduction in affinity beyond what the single substitution achieves alone
The physiologic advantage disappears
Low blood sugar (hypoglycemia) : This is more common in patients who are also taking other diabetes medications
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