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It could be responsible for maintaining homeostasis between DNA damage, senescence, and apoptosis under oxidative stress ( SIRT1 is redistributed at the chromatin level, causing deregulation at the transcription level and DNA damage ( SIRT-1 mRNA expression and induces apoptosis ( SIRT-1 can regulate cellular survival through its role in controlling iron hemostasis

10.1016/j.molcel.2016.04.033 236 RodriguezP

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Supplementation of some vitamins at higher doses level can cause toxicity