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2024 Feb 19;69:102475
Cardiovascular-Kidney-Metabolic (CKM) Syndrome , as defined by the AHA, is a systemic disorder characterized by pathophysiological interactions among metabolic risk factors (such as obesity, insulin resistance, dyslipidemia, and hypertension), chronic kidney disease (CKD), and the cardiovascular system, leading to multiorgan dysfunction and a high rate of adverse cardiovascular outcomes [145]
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From another investigation done, the aqueous extract was found to be potent enough to upregulate antioxidant SOD levels and downregulate DPP-IV mRNA expression, which apparently led to a concomitant reduction in stress, changes in the structural complexity of villi, increase of the intestinal patch, subsequent increase of the rate of nutrient absorption, and augmentation of GLP-1 and GIP secretion by causing an enhanced intestinotrophic effect (85)
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