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Further, the -helix fractions ( f a ) of SR18 calculated at 222 were found to be in the range of 0.034 in 1X PBS, 0.12 in 20% TFE, 0.22 in 20% HFIP, and 0.17 in 30 mM SDS (Supplementary Table S2), which is noted to be comparable with the reported value of 0.027 for semaglutide (Hamley et al., 2025)
This is particularly concerning given that dehydration may increase the risk of acute kidney injury, a rare but serious adverse effect associated with severe gastrointestinal reactions to GLP-1 receptor agonists
It was concluded that cotadutide can inhibit the production of key fats in the liver of mice and reduce the lipid content of the liver
While individual outcomes vary, research and clinical experience provide a reliable range that can help set realistic expectations
