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As this is the first study to assess such measures, the predictive value of these markers will become even more solidified as future studies are completed and similar protein concentrations can be compared on new and even larger populations from the DRC, as well as konzo affected communities in other countries of sub-Saharan Africa
Tesamorelin is a growth hormone-releasing hormone analog, while Ipamorelin is a peptide that stimulates growth hormone secretion
[10] The concurrent engagement of GHRH-R (via Modified GRF 1-29) and GHS-R1a (via Ipamorelin) at the somatotroph membrane may provide a convergent cAMP-dependent and calcium-dependent intracellular signaling environment, which research suggests might amplify GH secretory responses beyond those achievable by single-receptor stimulation
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