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Our group recently described that a genetic disruption of the xCT subunit using CRISPR-Cas9 inhibits protein synthesis and proliferation in vitro ( 14 C-cystine transport assay in xCT knockout (xCT-KO) cells revealed this transporter as unique and indispensible for cystine uptake, as a complete abolishment of cystine transport has been observed

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Deficiency of tetrahydrobiopterin, an essential cofactor for eNOS, has been shown to promote eNOS unpairing, which attenuates NO production and tends to enhance ROS production [75]

Current WADA status should be verified for competitive athletes