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Susceptibility to Oxidative Damage:Neuronal mitochondria are rich in polyunsaturated fatty acids (PUFAs), which are prone to lipid peroxidation by ROS, leading to membrane dysfunction and cellular damage
The progressive shifts in the maternal microbiome correspond to changes in the metabolite pool and the maternal immune system [23, 24]
Patients should continue evidence-based lipid-lowering therapy as recommended by NICE guidelines whilst considering GLP-1 therapy for its licensed indications
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