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Extra caution is important with: Frequent vomiting or suspected cannabinoid hyperemesis Symptoms of gastroparesis, including early fullness, nausea, vomiting, bloating, and upper abdominal pain Diabetes medications that can cause low blood sugar, including insulin or sulfonylureas Heavy cannabis use, high THC products, or unpredictable edibles dosing Prior dehydration, severe constipation, pancreatitis, or unexplained severe abdominal pain Very low appetite, unintended weight loss, or eating disorder history Multiple sedating substances Upcoming surgery, anesthesia, endoscopy, colonoscopy, or gastric emptying testing GLP-1 medications can delay gastric emptying, which also matters for procedures and anesthesia planning
This shift mirrors historical inflection points in other scientific domains, where progress accelerated not through incremental refinement, but through redefinition of the underlying framework
La tirzepatida est contraindicada en pacientes con historia personal o familiar de carcinoma medular de tiroides, sndrome de neoplasia endocrina mltiple tipo 2, o hipersensibilidad conocida al medicamento
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