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We also examined the role of glycosylation by introducing asparagine-to-alanine substitutions at six different potential N -glycosylation sites in surface-targeted LacAnc100, none of which appeared to notably reduce its activity (Supplementary Fig

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Studies have shown that in early PD patients with a disease duration of less than 4 years, iron accumulation in the SNpc occurs 4.19.6 years prior to the clinical diagnosis of PD and precedes SNpc neuromelanin (NM) lossa marker of dopaminergic neuronal degenerationby 2.63.7 years

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