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GLP-1 medications like Semaglutide and Tirzepatide are typically administered once weekly, and gradual, sustained weight loss occurs over several months
Of note, we found that neither ligand was capable of inducing detectable recruitment of G q , raising questions about the importance of signalling via this G protein in GLP-1R responses (Shigeto et al., 2015), although we cannot exclude cell type-specific effects
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