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Tirzepatide activates both the GIP receptor and the GLP-1 receptor, while semaglutide is a GLP-1 agonist only
It also helps your metabolism work more efficiently, which increases energy and supports weight loss
If you're seeing two or more of these, reduce training volume by 3040% for two weeks before making any other changes
Nausea is one of the most frequently reported side effects associated with retatrutide in clinical trials to date, as documented in the Phase 2 randomised controlled trial published in the New England Journal of Medicine in June 2023 (Jastreboff et al., NEJM 2023)
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