semaglutide tablets vs tirzepatide vs. Tirzepatide: MEDVi Launches Physician-Led Tirzepatide Vs Semaglutide: Which One

Available from: Aronson JK, Ferner RE

If you take metformin, start MOTS-c at 5 mg per week and monitor blood sugar closely

Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose

New England Journal of Medicine , NEJMoa2511774