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A meta-analysis of 113 RCTs comprising 33,167 patients in the GLP-1 RA cohort and 26,683 in the comparator cohort revealed no significant elevation in pancreatitis or pancreatic cancer risk relative to control groups (Mantel-Haenszel odds ratio [MH-OR] of 0.93 and 0.94, respectively), but identified a notable increase in cholelithiasis risk (MH-OR, 1.30) [58]

Gao Y, Zhang R, Liang H, Huang Y

The field awaits Phase 3 data to determine whether retatrutide's triple agonism translates into clinically meaningful advantages over the already substantial efficacy of tirzepatide