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Moreover, GPER activation has been shown to improve retinal structure and function, which can help mitigate visual impairments associated with vitamin A deficiency [117,118,119], involving the potential mechanism of regulating retinal neuron survival via oxidative damage and apoptosis
The peptide increases expression of 14 antioxidant genes while suppressing 2 pro-oxidant genes, creating a cellular environment more resistant to oxidative stress
These pharmacodynamic properties create two interaction surfaces with any compound that modulates serotonin or vascular tone: additive serotonergic toxicity and additive blood pressure effects
Additionally, they modulate key signaling pathways like Nrf2, PKA, and PI3K, thereby enhancing neuronal protection
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