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It is more like comparing a gentle tailwind to a jet engine

Low protein and calorie intake, electrolyte shifts like low sodium, and deficiencies in B12 or iron (low ferritin) can all cause: Fatigue Brain fog Depressed mood Before labeling Tirzepatide as the cause, I check: Daily protein intake, aiming for roughly 60 to 80 grams for many adults, depending on size and activity Hydration and salt intake should be considered if nausea or vomiting are present Labs: sodium, B12, ferritin, thyroid function, and glucose Who Might Be More At Risk For Mood Change On Tirzepatide

The recommendation to cycle off is based on caution, not hard evidence

Studies have been looking at how GLP-1s could have wider-reaching benefits related to impulse control