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The inhibitory effect of tamoxifen on UGT2B7 was dominated by hydrophobic and - stacking interactions, resulting in a concentration-dependent inhibition of UGT2B7 activity by tamoxifen and the imbalance of ligand-activated transcription factors, leading to abnormal regulation of UGT2B and disturbance of estrogen homeostasis, which in turn led to adverse reactions of tamoxifen
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Lipo C is generally well-tolerated, but injections can cause site reactions, and very high doses of some components could theoretically cause issues
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