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Under hypoxic conditions, cells activate adaptive responses mediated by hypoxia-inducible factor-1 (HIF-1), which regulates genes involved in angiogenesis, cell survival, and glucose metabolism

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Insulin-like growth factor 1 long arginine 3, animal component-free Overview IGF-I long arginine 3 (LR3) binds to insulin-like growth factor 1 (IGF-I) receptor and is a potent activator of the PI3K/AKT pathway and ERK1/2 signaling