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In intestinal L-cells - concentrated in the distal ileum and colon - PC1/3 processes proglucagon into GLP-1 , GLP-2, glicentin, and oxyntomodulin
But as these medications become the standard of care for obesity, an important question is emerging from the orthopedic and musculoskeletal literature: what happens to bone density and lean muscle mass during rapid, pharmacologically driven weight loss
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