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Future investigations should leverage the pleiotropy of GLP-1RAs to evaluate their effectiveness in treating multimorbidities, rather than focusing on a single health condition, particularly where obesity or other mechanistic pathways affected by GLP-1RAs are leading drivers, the authors write in their paper
Average weight loss in diabetes trials was 8 to 10 lbs at 30 weeks
This central GIPR activity is one reason tirzepatide reduces cravings and alters food preferences in ways patients frequently describe as different from their experience with GLP-1-only agents
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