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In vitro studies using mouse dorsal root ganglion neurons and induced pluripotent stem cell-derived human neurons have shown that vincristine disrupts mitochondrial dynamics, leading to increased ROS, mitochondrial fragmentation and axon degeneration (36,37), whereas studies in mouse models showed elevated ROS levels and increased apoptosis (37) Additional side effects of vincristine include myelosuppression (anemia, thrombocytopenia, bruising and bleeding), alopecia, nephrotoxicity and gastrointestinal toxicity (mucositis, nausea and vomiting) (38)

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