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By integrating microtranscriptomic, Limited Proteolysis-Small Molecule Mapping (LiP-SMap), and small molecule-protein interaction analysis, we find that uridine directly targets poly(rC)-binding protein 1 (PCBP1), thereby suppressing ferroptosis, maintaining mitochondrial function, alleviating oxidative damage, and ultimately improving the quality of aged oocytes

Laugero KD, Stonehouse AH, Guss S, Landry J, Vu C, Parkes DG

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