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The perception that tirzepatide "isn't working" may stem from unrealistic expectations about the speed or magnitude of results, inadequate dosing, lifestyle factors that counteract the medication's effects, or underlying medical conditions that interfere with its mechanism of action

These unquenched free radicals then turn inward, attacking the mitochondria themselvesdamaging mitochondrial DNA, essential transport proteins, and inner-membrane lipids like cardiolipin