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Deficiency in healthy individuals is rare
In rodent studies, animals with greater GLUT4 expression display heightened insulin sensitivity, whereas those with reduced GLUT4 levels demonstrate impaired insulin signaling
I.CuzicS.BrajsaK.MildnerB.BokulicA.SitumK.et al (2007)
Its ability to cross the bloodbrain barrier in laboratory models, combined with a relatively long plasma half-life compared to other small neuropeptides, has contributed to its enduring relevance in neurochemistry research
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