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In the light of the current research, it is speculated that the maladaptive changes in the gut microbiota can influence the central nervous system and evoke depressive symptoms, and the development of depression can influence gut microbiome stability, and both of these hypotheses appear to be supported by the results of human and animal studies [100]
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Histopathologically, these lesions are composed of either lentigo simplex, melanocytic hyperplasia, or a lentiginous junctional nevic component, overlapping a background hyperpigmented macule
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