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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]

We constructed natural product-gene-pathway networks for (-)-Vestitol and Salviolone on the basis of their corresponding pathways and genes

It is clinically defined by progressive cognitive decline, particularly in memory, language, executive function, and orientation, which in time culminates in significant loss of independence and diminished quality of life