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The central clinical idea: when mitochondrial ATP production falls and oxidative stress rises, the brain may lose the energy and antioxidant reserve needed to regulate neurotransmission, maintain cell membranes, recycle methionine, produce SAM, clear adenosine and homocysteine, build glutathione and tolerate medications or supplements

Multiple randomized controlled trials and a 2024 meta-analysis of 20 studies confirm that oral NAC supplementation raises glutathione concentrations in humans

Bacterial endotoxins, he says, can do a "serious number on you"

(eds) Mushroom Bioactives: Bridging Food, Biotechnology, and Nanotechnology for Health and Innovation