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Younger individuals with robust natural GH production typically see less dramatic improvement
To ensure optimal Exe4 secretion from hepatic cells, we engineered a series of secreted Exe4 expression plasmids with various SP (NGF, IgK, and ProEx4) and FCS (FCS1 and FCS2) combinations, and transfected them into hepatic Hepa1-6 and HepG2 cells (Supplementary Table 1) 26,27,28,29,30,31,32
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