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Lu Author profile: Cedars-Sinai Research Profile Shelly C
Vasavada A, Patel P, Sanghavi DK
Postmortem studies of PD brains have demonstrated microglial activation in the substantia nigra pars compacta (SNpc), characterized by increased expression of markers such as HLA-DR, CD68, and Iba-1, along with elevated production of pro-inflammatory mediators including IL-1, TNF-, IL-6, and reactive oxygen species (ROS) [73]
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