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In the degradation pathway of AX, other structures such as amoxicilloic acid (result from -lactam ring hydrolysis) and diketopiperazine (resulting from intramolecular acylation by the amino group of AX side chain) can be formed 19

Inverse data-driven modeling and multiomics analysis reveals phgdh as a metabolic checkpoint of macrophage polarization and proliferation

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These results support the notion that enhanced GST-mediated conjugation represents a key mechanism contributing to CF resistance in recurrent EC and highlight the potential value of evaluating multiple GST genes rather than a single marker