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AstraZeneca were not involved in the distribution of the Delphi survey, or the collection and analysis of responses
Before being sold to the public, these products do not have the same clinical trials to determine their safety and efficacy
It acts as a non-selective melanocortin receptor agonist with the following binding profile (approximate Ki values): MC1R : ~0.67 nM (highest affinity, melanogenesis) MC4R : ~6.6 nM (appetite suppression, sexual function) MC3R : ~34 nM (energy balance) MC5R : ~46 nM (exocrine gland function) This broad receptor profile produces multiple physiological effects
doi:10.1073/PNAS.1611576114/-/DCSUPPLEMENTAL 7
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