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This is associated with reduced noradrenaline content in the pancreas and blocked by an 2 -adrenergic receptor agonist, implicating functional involvement of the sympathetic nervous system (SNS)
Kuhn HG, Winkler J, Kempermann G, Thal LJ, Gage FH
Delayed ISRs (happening within days post-injection) can also be observed and are known to be driven by additional inflammatory mechanisms, most notably the recruitment of peripheral blood immune cells to the site of injection
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