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Elevated 6PGD and its product Ru5P inhibit AMPK activation by disrupting the active LKB1 complex, which promotes lipogenesis by abolishing AMPK-dependent acetyl-CoA carboxylase 1 (ACC1) phosphorylation and inactivation (90)
Biological trace element research
4, Supplementary Fig
362 Additionally, copper ionophores or copper-ligand complexes (e.g., elesclomol) are being explored to selectively induce cuproptosis in tumor cells with active mitochondrial metabolism
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