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One approach is the use of sildenafil (Watkins et al., 2000), a phosphodiesterase-5 inhibitor which mimics the effect of nitric oxide by increasing intracellular cGMP
Bioorganic & Medicinal Chemistry, 26 (10), 27002707
Regarding injection frequency, tirzepatides once-weekly injection method shows significant advantages in weight loss and glycemic control, improving patient compliance more effectively than daily injections, such as liraglutide
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