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During the early stages, nausea is one of the most common symptoms, which often improves as you approach your target dose
Hypoxic conditions can also lead to a phenomenon known as DPP-4 shedding whereby transmembrane DPP-4 is cleaved from the membrane and released into the circulation in a soluble form
Through neural pathways as well as via receptor-mediated effects, GLP-1 reduces postprandial hyperglycemia by stimulation of insulin secretion, suppression of glucagon release, inhibition of gastric emptying and small intestinal peristalsis, and induction of satiety which limits meal size [17]
Bottom line Stopping Mounjaro without a plan is one of the most predictable clinical mistakes in this space
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