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The SURMOUNT-5 head-to-head trial demonstrated tirzepatide produces 47% more weight loss than semaglutide (20.2% vs 13.7%)

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Studies have shown the propensity for inaccuracy in coding for DR, 28 particularly after hospital systems switched from ICD-9 to ICD-10 coding, 29 and a recent study highlighted the difference in coding for DR severity between retina specialists and general ophthalmologists

For comparison, semaglutide alone produced 14.9% weight loss, cagrilintide alone produced 11.5%, and placebo delivered just 3%