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Photoprotection in EPP (approved use): As a 16 mg implant, afamelanotide increased pain-free time in direct sunlight and improved quality of life in adults with erythropoietic protoporphyria [1]
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The DRI modification makes the peptide backbone unrecognizable to endogenous aminopeptidases, carboxypeptidases, and endopeptidases, extending functional persistence from minutes to an estimated hours-to-days range
Theoretical risks of sustained angiogenic stimulation (promoting vascular supply to undetected pathological tissue) grow proportionally with the duration of use, as cumulative VEGF upregulation exceeds the controlled, injury-localized window intended by short-cycle research protocols
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