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Other randomized clinical trials, whose main objective was to reduce macro and microvascular outcomes, were conducted, such as the ACCORD study (Action to Control Cardiovascular Risk in Diabetes) [38], ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) [39] and the VADT (Veterans Affair Diabetes Trial) [40]

A healthy lifestyle should always be the foundation for obesity treatment, but wider access to medications is greatly needed

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Decombaz, J., Deriaz, O., Acheson, K., Gmuender, B., and Jequier, E