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Discontinue use if irritation, redness or discomfort develops
10.1146/annurev-biochem-063011-092449 225 NaguibM.FloodP.McardleJ
Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]
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